Sodium Hydroxide → HCID 19770973, compound

HRID 1589845Notes

Reaction equation

HRID 1589845 reaction equation
[CH2:1]([C:4]1[N:9]2[N:10]=[CH:11][C:12]([C:13]([O:15]CC)=[O:14])=[C:8]2[CH:7]=[CH:6][CH:5]=1)[CH2:2][CH3:3].[OH-].[Na+]>C(O)C>[CH2:1]([C:4]1[N:9]2[N:10]=[CH:11][C:12]([C:13]([OH:15])=[O:14])=[C:8]2[CH:7]=[CH:6][CH:5]=1)[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19770956HCID 19770956, compound

Product 1

HCID 19770973HCID 19770973, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
100 °C

Procedure

To 0 46 g (1.98 mmol) of ethyl 7-propylpyrazolo[1,5-a]pyridine-3-carboxylate, 8 ml of 2.5N aq. NaOH solution and 5 m; of ethanol were added, followed by stirring at 100° C. for 3 hours. After the reaction, post treatments were conducted in a similar manner to the syntheses of the 5-methyl and 2,7-dimethyl derivatives so that 0.37 g (1.81 mmol) of crystals of the title compound were obtained (Yield: 91%).

Workup

  1. customAfter the reaction, post treatments

Sources & evidence

ORD record
ord-c530841dc4064c12a970904d48427c50
Source dataset
uspto-grants-1993_04
Patent number
US05200415

Reaction notes

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