Aminoisobutyric acid → Methyl 2-aminoisobutyrate hydrochloride

HRID 1589883Notes

Reaction equation

HRID 1589883 reaction equation
[CH3:1][C:2]([CH3:7])([C:4]([OH:6])=[O:5])[NH2:3].[CH3:8][Si]([Cl:12])(C)C>CO>[ClH:12].[CH3:8][O:5][C:4](=[O:6])[C:2]([CH3:7])([CH3:1])[NH2:3]

Participants

4

Reactant 2

HCID 6119Aminoisobutyric acidHCID 6397Chlorotrimethylsilane

Product 1

HCID 13258034Methyl 2-aminoisobutyrate hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a stirred solution of 2,2-dimethylglycine (10.0 g, 0.097 mol) in methanol (200 ml) was added trimethylsilyl chloride (37 ml, 0.29 mol). After stirring at room temperature for 14 h. The mixture was evaporated to dryness to give crude 2,2-dimethylglycine methyl ester hydrochloride as a white solid which was used directly in the next step.

Workup

  1. customThe mixture was evaporated to dryness

Sources & evidence

ORD record
ord-3216b2b0e7924fb3a1bde17b93af9a5a
Source dataset
uspto-grants-1993_04
Patent number
US05200412

Reaction notes

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