HCID 19771308, compound → HCID 19771310, compound

Participants

Reaction Conditions

Reaction Steps

38.7 g (146 mmol) 1-(4-chlorobenzyl)-1,2-epoxy-4,4-dimethylcyclohexan-3-one obtained in Example 2 above was added to a slurry of potassium tert-butoxide (33 g, 294 mmol) in tert-butanol (200 ml) at 40° C. The mixture was then warmed to 60 C and stirred for 2 hours before being cooled in ice and quenched with water (50 ml). 5M Hydrochloric acid (100 ml) was then added slowly followed by water (300 ml). The mixture was then cooled to 0° C., filtered and the residue washed with water (100 ml). Drying under vacuum at 40° C. gave 36.3 g 1-(4-chlorobenzyl)-2-hydroxy-4,4-dimethylcyclohex-1-en-3-one, m.pt. 80-82° C.

Provenance & Evidence