Alpha-methyldopa → HCID 53997397, compound

Participants

Reaction Steps

The procedure of Example 1 is repeated employing 2-amino-2-methyl-3-(3,4-dihydroxyphenyl)propionic acid rather than 2-hydrazino-2-methyl-3-(4-hydroxy-3-methoxyphenyl)propionic acid. The (±)-butyl 2-amino-2-methyl-3-(3,4-dihydroxyphenyl)propionate is obtained in a yield of 82%. The product is recrystallized from acetonitrile (77% yield) to give pure ester: mp 121.5° C. to 122° C.; HPLC analysis (C-18 column, 280 nm, tR =14.5 min) showed >99% purity.

Provenance & Evidence