反应详情

6-Chloroimidazo[1,2-b]pyridazine (7.68 g) was added to 150 ml of carbon tetrachloride, to which 7.0 g of N-chlorossuccinimide were added and refluxed for 2 hours. After cooling, the precipitated crystals were filtered off. The filtrate was washed in turn with 1N-sodium hydroxide aqueous solution, 1N-hydrochloric acid and water, dried over anhydrous magnesium sulfate and distilled to remove the solvent. The residue was washed with diethyl ether to obtain 7.13 g of 3.6-dichloroimidazo[1,2-b]pyridazine.

1. additionwere added
2. temperaturerefluxed for 2 hours
3. temperatureAfter cooling
4. filtrationthe precipitated crystals were filtered off
5. washThe filtrate was washed in turn with 1N-sodium hydroxide aqueous solution, 1N-hydrochloric acid and water
6. dry with materialdried over anhydrous magnesium sulfate
7. distillationdistilled
8. customto remove the solvent
9. washThe residue was washed with diethyl ether