Imidazo(1,2-b)pyridazine, 6-chloro- → Sodium 2-[(imidazo[1,2-b]pyridazin-6-yl)thio]ethanesulfonate

HRID 1590062Notes

Reaction equation

HRID 1590062 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[N:7]=1.[SH:11][CH2:12][CH2:13][S:14]([O-:17])(=[O:16])=[O:15].[Na+:18].CO.[Na]>CO>[N:10]1[CH:9]=[CH:8][N:6]2[C:5]=1[CH:4]=[CH:3][C:2]([S:11][CH2:12][CH2:13][S:14]([O-:17])(=[O:16])=[O:15])=[N:7]2.[Na+:18]

Participants

5

Reactant 3

HCID 138828Imidazo(1,2-b)pyridazine, 6-chloro-HCID 23662354MesnaHCID 86653488Methanol sodium

Product 1

HCID 23700851Sodium 2-[(imidazo[1,2-b]pyridazin-6-yl)thio]ethanesulfonateYield 80.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 1.35 g of 6-chloroimidazo[1,2-b]pyridazine in 30 ml of methanol were added 1.45 g of sodium 2-mercaptoethanesulfonate and 1.80 ml of 28 W/W % sodium-methanol solution, followed by refluxing for 5 hours. The precipitated crystals were collected by filtration and washed with methanol to obtain 1.98 g of sodium 2-[(imidazo[1,2-b]pyridazin-6-yl)thio]ethanesulfonate.

Workup

  1. temperatureby refluxing for 5 hours
  2. filtrationThe precipitated crystals were collected by filtration
  3. washwashed with methanol

Sources & evidence

ORD record
ord-8e1ca44ec6424f899115e44a0025e9d4
Source dataset
uspto-grants-1993_04
Patent number
US05202324

Reaction notes

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