反应详情

To a solution of 0.37 g of 3-mercapto-2,2-dimethyl-1-propylsulfonamide and 0.37 g of 28% sodium methoxide-methanol solution in 50 ml of methanol was added 0.31 g of 6-chloroimidazo[1,2-b]pyridazine, followed by refluxing at 80°-85° C. for 3 hours. The reaction solution was concentrated under reduced pressure. The residue to which 30 ml of water were added was extracted with tetrahydrofuran and ethyl acetate (1:1). The extract was dried over anhydrous magnesium sulfate and distilled under reduced pressure to remove the solvent. The residue was recrystallized from ethanol to obtain 0.4 g of the title compound.

1. temperatureby refluxing at 80°-85° C. for 3 hours
2. concentrationThe reaction solution was concentrated under reduced pressure
3. additionThe residue to which 30 ml of water were added
4. extractionwas extracted with tetrahydrofuran and ethyl acetate (1:1)
5. dry with materialThe extract was dried over anhydrous magnesium sulfate
6. distillationdistilled under reduced pressure
7. customto remove the solvent
8. customThe residue was recrystallized from ethanol