HCID 86746698, compound → HCID 9806505, compound

Participants

Reaction Steps

10% Pd/C (0.026 gm, 0.024 mmol) was added to a methanol solution (30 ml) of (S)-4-[[2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-phenyl-5-pyrimidinyl]ethenyl]methoxyphosphinyl]-3-hydroxybutanoic acid, methyl ester obtained in Example 3 above (0.125 gm, 0.24 mmol) which had been purged with argon for 15 minutes. The solution was then placed under 50 psi of hydrogen on a Parr apparatus and shaken for 6 days. The flask was then taken off the Parr apparatus and the solution filtered through a pad of celite which was washed with methanol. The filtrate was concentrated to give a clear oil which was subsequently purified by flash chromatography on Merck silica gel in 30-70% acetone in hexane. Product fractions were combined and concentrated to afford the title compound as a white solid (0.080 gm, 64%). TLC: Rf =0.41 (50% acetone in hexane).

Provenance & Evidence