4,7-Dichloroquinoline → HCID 19769530, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1.17 g of 4,7-dichloroquinoline, 1.0 g of 4,6-dimethyl-2-mercaptopyrimidine and 3 ml of N,N-dime thylimidazolidinone was heated at 80° C. for 1 hour. The reaction mixture was cooled and separated by column chromatography(n-hexane/ethyl acetate=1/1) to obtain 7-chloro-4-(4,6-dimethyl-2-pyrimidinylthio)-quinoline. Yield was 0.83 g. Melting point was 127.4°-129.5° C.

Provenance & Evidence