Sodium Hydroxide → Vamicamide

Participants

Reaction Steps

To a solution of (±)-(2R*,4R*)-4-dimethylamino-2-phenyl-2-(2-pyridyl)valeramide hydrochloride (20 g) in water (80 ml) were added seed crystals (0.02 g) and a solution of sodium hydroxide (2.47 g) in water (80 ml) was dropwise added thereto at 20-25° C. over a period of 30 minutes. The mixture was stirred at the same temperature for 1 hour. The resulting crystals were recovered by filtration, washed with water and dried to give (±)-(2R*,4R*)-4-dimethylamino-2-phenyl-2-(2-pyridyl)-valeramide (16.1 g).

Provenance & Evidence