HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl mercaptan → HCID 14980527, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl mercaptan | HCID 6387 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | HCID 14980526 | HCID 14980526 | — |
| Catalyst | Tetrabutylammonium Bromide | HCID 74236 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 14980527 | HCID 14980527 | — |
Reaction Steps
A solution of the α-chloroketone (1 eq) from Step 5, 2-methyl-2-propanethiol (1.2 eq), Et3N (1.5 eq) and n-Bu4NBr (catalytic amount) in THF at room temperature under nitrogen was stirred for 24 hours. The mixture was filtered and the solvent removed in vacuo. Chromatography of the oily residue on silica gel (hexane/EtOAc 10:1) provide the title compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05202321 |
| Source dataset | uspto-grants-1993_04 |
| ORD ID | ord-b0189d5e71c24f9787f61d085d499406 |
| Source note | uspto-grants-1993_04 |