Lithium Hydroxide → HCID 14980568, compound

Participants

Reaction Steps

To a solution of diester from Step 3 (4.5 g, 9.46 mmol) in MeOH (90 mL) there was added 1N LiOH (50 mL) and the mixture was stirred for 1 hour at r.t. It was then diluted with H2O and extracted twice with Et2O. The aqueous fraction was then acidified with 6N HCl and extracted 4 times with Et2O. These extracts were washed 4 times with H2O, dried and evaporated to yield the title compound as a thick oil.

Provenance & Evidence