Ammonia → HCID 178454151, compound

Participants

Reaction Steps

N-tert-butoxycarbonyl-L-phenylalanyl-L-phenylalanyl-L-histidine methyl ester (2 g) is dissolved in a methanol solution saturated with ammonia, and the solution is stirred in a pressure bottle at room temperature for three days. The reaction mixture is concentrated under reduced pressure and the residue is crystallized with ether to give N-tert-butoxycarbonyl-L-phenylalanyl-L-phenylalanyl-L-histidine amide (1.7 g) as white crystals. Yield: 87.2%

Provenance & Evidence