HCID 19100944, compound → HCID 22924404, compound

HRID 1590158Notes

Reaction equation

HRID 1590158 reaction equation
C([N:8]1[CH2:15][CH2:14][C:13]2([CH3:16])[CH:9]1[CH2:10][N:11]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:12]2)C1C=CC=CC=1>[Pd].C(O)C>[CH3:16][C:13]12[CH2:12][N:11]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:10][CH:9]1[NH:8][CH2:15][CH2:14]2

Participants

4

Reactant 1

HCID 19100944HCID 19100944, compound

Product 1

HCID 22924404HCID 22924404, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

2.6 9 (10.3 mmol) of tert.-butyl 2-benzyl-5-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate in50 ml of ethanol are hydrogenated on 0.5 g of palladium/active carbon (10% Pd) at 130° C. and 100 bar. The catalyst is filtered off with suction, and the liquid phase is concentrated and distilled.

Workup

  1. filtrationThe catalyst is filtered off with suction
  2. concentrationthe liquid phase is concentrated
  3. distillationdistilled

Sources & evidence

ORD record
ord-f21b7951f8ea45d298f19420cbe23374
Source dataset
uspto-grants-1993_04
Patent number
US05202337

Reaction notes

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