1,1'-Thiocarbonyldiimidazole → HCID 9952107, compound

Participants

Reaction Steps

To a solution of N-[2-(4-methoxybenzylthio)-2-methylpropyl]-L-cysteine methyl ester (5.0 g) in chloroform (90 ml), thiocarbonyldiimidazole (3.0 g) was added and the mixture was stirred for 1 hr at room temperature. The reaction mixture was washed with 3N hydrochloric acid, water and then saturated sodium chloride solution, dried over anhydrous magnesium sulfate, and concentrated in vacuo. The crude product was recrystallized from ethyl acetate to give 5.1 g (91%) of the titled compound.

Provenance & Evidence