Hydrochloric Acid → HCID 10339094, compound

Participants

Reaction Steps

To a solution of N-[2-(4-methoxybenzylthio)-2-methylpropyl]-L-cysteine methyl ester (0.5 g) in dimethylformamide (10 ml), carbonyldiimidazole (0.28 g) was added and the mixture was stirred for 2.5 hours at 100°-110° C. 1N hydrochloric acid was added into the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was washed with 1N hydrochloric acid, water and then saturated sodium chloride solution, dried over magnesium sulfate, and concentrated in vacuo. The oily residue was purified by a silica gel column chromatography and recrystallized from n-hexane--isopropanol to give 0.22 g (40%) of the titled compound.

Provenance & Evidence