46324-06-5 → HCID 10686666, 화합물

HRID 1590172노트

반응식

HRID 1590172 반응식
[CH:1](=[C:8]1/[C:9]([O:11][C:12](=[O:14])[CH2:13]/1)=[O:10])\[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:15]1[C@@H:23]2[C@@H:18]([CH2:19][CH2:20][CH2:21][CH2:22]2)[CH2:17][NH:16]1>ClCCl>[CH:1](=[C:8](/[CH2:13][C:12]([N:16]1[CH2:17][C@H:18]2[C@H:23]([CH2:22][CH2:21][CH2:20][CH2:19]2)[CH2:15]1)=[O:14])\[C:9]([OH:11])=[O:10])/[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 592539046324-06-5HCID 10964494cis-Octahydroisoindole

생성물 1

HCID 10686666HCID 10686666, 화합물수율 84.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a suspension of (E)-benzylidenesuccinic anhydride (13.9 g) in dichloromethane (120 ml) was added cis-hexahydroisoindoline (12.0 g) and the mixture was stirred at room temperature for 2 hours. The reaction mixture was washed successively with 1N hydrochloric acid and brine and dried over MgSO4. After the solvent was evaporated under reduced pressure, the residue was crystallized from ethyl acetate to give 19.5 g of (E)-2-benzylidene-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid.

후처리

  1. washThe reaction mixture was washed successively with 1N hydrochloric acid and brine
  2. dry with materialdried over MgSO4
  3. customAfter the solvent was evaporated under reduced pressure
  4. customthe residue was crystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-9f5f6fb3a753416a9ff9275257eed374
출처 데이터셋
uspto-grants-1993_04
특허 번호
US05202335

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