Sodium Hydroxide → sodium (E)-2-benzylidene-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionate

HRID 1590174Notes

Reaction equation

HRID 1590174 reaction equation
[CH:1](=[C:8](/[CH2:12][C:13]([N:15]1[CH2:23][C@H:22]2[C@H:17]([CH2:18][CH2:19][CH2:20][CH2:21]2)[CH2:16]1)=[O:14])\[C:9]([OH:11])=[O:10])/[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+:25]>C(O)C>[CH:1](=[C:8](/[CH2:12][C:13]([N:15]1[CH2:16][C@H:17]2[C@H:22]([CH2:21][CH2:20][CH2:19][CH2:18]2)[CH2:23]1)=[O:14])\[C:9]([O-:11])=[O:10])/[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1.[Na+:25]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 10686666HCID 10686666, compound

Product 1

HCID 67760534sodium (E)-2-benzylidene-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of (E)-2-benzylidene-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid (31 mg) in ethanol (0.3 ml) was added 1N sodium hydroxide solution (0.1 ml) and the mixture was stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure to give 30 mg of sodium (E)-2-benzylidene-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionate as a colorless amorphous solid.

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-f9719fb9ea384a7786189952c7c84867
Source dataset
uspto-grants-1993_04
Patent number
US05202335

Reaction notes

Loading…