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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1590175Generated: October 30, 2026

Diazomethane → methyl (E)-2-benzylidene-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionate

https://huagongshe.com/reaction/1590175

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiazomethaneHCID 9550—
ReactantHCID 10686666HCID 10686666—
SolventDiethyl EtherHCID 3283—
Productmethyl (E)-2-benzylidene-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionateHCID 67759421—

Reaction Steps

To a solution of (E)-2-benzylidene-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid (50 mg) in diethyl ether was added a solution of diazomethane in diethyl ether with stirring and the mixture was stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure to give 52 mg of methyl (E)-2-benzylidene-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionate as a colorless viscous oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05202335
Source datasetuspto-grants-1993_04
ORD IDord-06e45250b7d84e03a829dfbdc3f6ef45
Source noteuspto-grants-1993_04