HCID 18651164, compound → HCID 54078901, compound

Participants

Reaction Steps

To a suspension of (E)-3-(cis-hexahydro-2-isoindolinylcarbonyl)-2-(2-thenylidene)propionic acid (150 mg) in ethanol (20 ml) was added 10% Pd-C (70 mg) and the mixture was hydrogenated at room temperature and atmospheric pressure for 16 hours. After the catalyst was filtered off, the solvent was evaporated under reduced pressure. The residue was purified by thin layer chromatography (mobile phase: dichloromethane/methanol=15/1) to give 30 mg of 3-(cis-hexahydro-2-isoindolinylcarbonyl)-2-(2-thenyl)propionic acid as a pale yellow viscous oil.

Provenance & Evidence