Triethylamine → HCID 19769912, compound

Participants

Reaction Conditions

Reaction Steps

To 1 g (6.41 mmol) of 2,6-dimethoxybenzoic acid, were added 10 ml of toluene, 1.05 ml (6.79 mmol) of triethylamine and 1.41 ml (6.54 mmol) of diphenylphosphoryl azide and stirred at 100° C. for one hour. The reaction solution was cooled to room temperature, then added with a 5 ml of toluene solution of 1.40 g (6.41 mmol) of 2-(3,4-methylenedioxyphenyl)-hexylamine and stirred overnight at room temperature. The thus treated reaction solution was purified by silica gel column chromatography (developed with a 2/1 mixture of hexane and ethyl acetate) and then recrystallized from the hexane/ethyl acetate mixed solvent to obtain 330 mg of 1-(2-(3,4-methylenedioxyphenyl)hexyl)-3-(2,6-dimethyoxyphenyl)urea (yield: 12.9%).

Provenance & Evidence