Triethylamine → HCID 19769917, compound

Participants

Reaction Conditions

Reaction Steps

To 800 mg (3.20 mmol) of 2-(2,3-methylenedioxyphenyl)heptanoic acid, were added 10 ml of toluene, 0.59 ml (3.84 mmol) of triethylamine and 1.0 ml (4.8 mmol) of diphenylphosphoryl azide, and the mixture was stirred at 100° C. for one hour. After cooling the mixture to room temperature, 5 ml of a toluene solution containing 570 mg (3.20 mmol) of 2,6-diisopropylaniline was added and the mixture was stirred at room temperature over night. The reaction mixture was subjected to purification by silica-gel column chromatography (eluent: hexane/ethyl acetate=5/1) and recrystallization from a mixed solvent of hexane and ethyl acetate to obtain 510 mg of 1-(1-(2,3-methylenedioxyphenyl)hexyl)-3-(2,6-diisopropylphenyl)urea (Yield: 38%).

Provenance & Evidence