Diethyl Ether → HCID 54112566, compound

HRID 1590215Notes

Reaction equation

HRID 1590215 reaction equation
CCOCC.[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH2:12]1[O:20][C:19]2[CH:18]=[CH:17][C:16]([CH:21]([CH2:25][CH2:26][CH2:27][CH2:28]C)[C:22](O)=[O:23])=[CH:15][C:14]=2[O:13]1>O>[CH2:12]1[O:20][C:19]2[CH:18]=[CH:17][C:16]([CH:21]([CH2:25][CH2:26][CH2:27][CH3:28])[CH2:22][OH:23])=[CH:15][C:14]=2[O:13]1

Participants

5

Reactant 3

HCID 3283Diethyl Ether2×HCID 19769911HCID 19769911, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 54112566HCID 54112566, compoundYield 99.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 40 ml of ether suspension containing 1.74 g (46 mmol) of lithium aluminum hydride, was added dropwise under cooling with ice 40 ml of ether solution containing 10.9 g (46 mmol) of (-)-2-(3,4-methylenedioxyphenyl)-heptanoic acid obtained in Reference Example 2. After 2-hour reflux, the reaction mixture was cooled to room temperature and was treated with water under cooling with ice to obtain 10.2 g of oily 2-(3,4-methylenedioxyphenyl)hexyl alcohol.

Workup

  1. additionwas added dropwise
  2. customobtained in Reference Example 2
  3. temperatureAfter 2-hour reflux
  4. temperatureunder cooling with ice

Sources & evidence

ORD record
ord-808cb5ae562343d8b2cb52ade2b908a1
Source dataset
uspto-grants-1993_04
Patent number
US05202351

Reaction notes

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