Triethylamine → HCID 67795255, compound

Participants

Reaction Steps

To a solution of the aminopyrrolidinone of Example R (120 mg, 0.495 mmol) and triethylamine (0.35 ml, 2.48 mmol) in CH2Cl2 was added a solution of 2-naphthoyl chloride (94 mg, 0.495 mmol) in CH2Cl2 dropwise via syringe. After stirring for 12 h at room temperature the reaction mixture was evaporated in vacuo to give a residue which was chromatographed on silica gel eluting with EtOH/CH2Cl2 (2%-5%) to give the title compound (172 mg, 69%) as a colorless solid. MS M+1 calcd for C23H28N2O4 397; found 397.

Provenance & Evidence