反应详情

According to the procedure of Southwick [J. Org. Chem. 21, 1087 (1956)]the ethyl ester pyrrolidinone of Example S (1.0 g, 4.0 mmol) was suspended in 75 ml of 20% HCl/H2O and refluxed for 3.5 h The reaction was cooled and filtered and the filtrate was extracted with CHCl3 (4×150 ml). Concentration of the combined extracts gave an off-white solid (358 mg). 'NMR(300 MHZ, CDCl3) δ2.92 (t, 2H), 4.17 (t, 2H), 7.32 (t, 1H), 7.98 (t, 2H), 7.84 (d, 2H).

1. temperaturerefluxed for 3.5 h The reaction
2. temperaturewas cooled
3. filtrationfiltered
4. extractionthe filtrate was extracted with CHCl3 (4×150 ml)