Ethyl 4-(hydroxyimino)-5-oxo-1-phenyl-3-pyrrolidineacetate → Ethyl 4-amino-5-oxo-1-phenyl-3-pyrrolidineacetate

HRID 1590263Notes

Reaction equation

HRID 1590263 reaction equation
O[N:2]=[C:3]1[C:7](=[O:8])[N:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:5][CH:4]1[CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17]>CCO.[Pd]>[NH2:2][CH:3]1[C:7](=[O:8])[N:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:5][CH:4]1[CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17]

Participants

4

Reactant 1

HCID 86746704Ethyl 4-(hydroxyimino)-5-oxo-1-phenyl-3-pyrrolidineacetate

Product 1

HCID 53812745Ethyl 4-amino-5-oxo-1-phenyl-3-pyrrolidineacetate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of the product of example 63 in EtOH is hydrogenated with 10% palladium on carbon at 60 psi at 60° C. Filtration and purification of the product on silica gel affords the title compound.

Workup

  1. filtrationFiltration and purification of the product on silica gel

Sources & evidence

ORD record
ord-94443052e77947e6a11a1037376c5370
Source dataset
uspto-grants-1993_04
Patent number
US05202344

Reaction notes

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