化工社化工社 化学情報印刷レポート · 研究参考用
Diethyl Ether → HCID 57153373、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | 2-(Methoxymethyl)pyrrolidin-1-amine | HCID 143663 | — |
| 反応物 | 1-Phenylpyrrolidine-2,3-dione | HCID 19023571 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | HCID 57153373 | HCID 57153373 | — |
反応手順
A solution of the product of Example 61 and chiral 1-amino-2-methoxymethylpyrrolidine (SAMP or RAMP; 1 equiv) in benzene is refluxed under Dean-Stark conditions for 20 h After cooling, Et2O is added and the mixture is washed with water. The organic layer is dried (MgO4), and evaporated to give a residue which is chromatographed on silica gel to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05202344 |
| 出典データセット | uspto-grants-1993_04 |
| ORD ID | ord-4025d25706be4a47bd53045e959c41ba |
| 出典メモ | uspto-grants-1993_04 |