Malononitrile → 1-cyclopropyl-4,6-diamino-2(1H)-pyrimidinethione

HRID 1590268Notes

Reaction equation

[CH:1]1([NH:4][C:5]([NH2:7])=[S:6])[CH2:3][CH2:2]1.[C:8](#[N:12])[CH2:9][C:10]#[N:11]>>[CH:1]1([N:4]2[C:10]([NH2:11])=[CH:9][C:8]([NH2:12])=[N:7][C:5]2=[S:6])[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 8010Malononitrile

HCID 2560481Cyclopropylthiourea

Product 1

HCID 197692121-cyclopropyl-4,6-diamino-2(1H)-pyrimidinethioneYield 38%

Procedure

N-cyclopropylthiourea (6.2 g) and malononitrile (6.6 g) were reacted in the same method as described in Preparation 12 to give the pale yellow above-indicated compound(3.7 g).

Workup

customas described in Preparation 12

Sources & evidence

ORD record: ord-bdae9684b50b40ec9ccd9a5cfa9ba30a
Source dataset: uspto-grants-1993_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05202315

Reaction notes

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