Sodium Acetate → HCID 86746708, compound

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Reaction Steps

A mixture of 2-[[2-(methylthio)phenyl]methylene]-3-oxobutanoic acid, ethyl ester (2.0 g., 7.5 mmole), S-(4-methoxybenzyl)thiopseudourea, hydrochloride (1.76 g., 7.5 mmole) and sodium acetate (0.66 g. 8.0 mmole) in dimethylformamide (10 ml.) is stirred and heated at 70° for 6 hours. The cooled mixture is diluted with ether and washed with water, sodium bicarbonate, and brine. The dried solution is evaporated to give 3.0 g. of an oil. Flash chromatography using ethyl acetate:hexanes (1:4) gives 2.13 g. of 1,4-dihydro2-[[(4-methoxybenzyl)methyl]thio]-6-methyl-4-[2-(methylthio)phenyl]-5-pyrimidinecarboxylic acid, ethyl ester as a yellow oil.

Provenance & Evidence