HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (2,6-Dichloropyridin-4-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2,6-Dichloro-isonicotinic acid ethyl ester | HCID 94823 | — |
| Reactant | Diisobutylaluminumhydride | HCID 21225700 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (2,6-Dichloropyridin-4-yl)methanol | HCID 2794840 | — |
Reaction Steps
The above ester was dissolved in dichloromethane (60 ml) and cooled to -20° under nitrogen. Diisobutylaluminium hydride (38 ml) was added dropwise. After 2 hours at 0°, dilute hydrochloric acid was carefully added and the mixture worked up in the usual manner to give 2,6-dichloro-4-hydroxymethylpyridine. NMR 1H: 7.64(2H,s), 4.98(2H,s).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05202356 |
| Source dataset | uspto-grants-1993_04 |
| ORD ID | ord-4c407586f22b41fbbaeed9084d58ba64 |
| Source note | uspto-grants-1993_04 |