Hydrochloric Acid → HCID 18651184, compound

Participants

Reaction Steps

The above ester (4 g) was dissolved in dichloromethane (30 ml) and cooled to -20° under nitrogen. Diisobutylaluminium hydride (26 ml) was added dropwise. After 18 hours at 25° dilate hydrochloric acid was carefully added and the mixture worked up in the usual manner to give (±)-(2Z)-3-[trans-2-(3,4-dichlorophenyl)cyclopropyl]-2-fluoroprop-2-en-1-ol (3.3 g). NMR 1H: 7.32(1H,d), 7.17(1H,d), 6.90(1H,dd), 4.10(2H,dd), 3.60(1H,t), 1.90(2H,m), 1.20(2H,m).

Provenance & Evidence