HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylamine → HCID 131717858, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylamine | HCID 7912 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | HCID 18651187 | HCID 18651187 | — |
| Reactant | HCID 131717859 | HCID 131717859 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 131717858 | HCID 131717858 | — |
Reaction Steps
A solution of lithium diisopropylamide in tetrahydrofuran under nitrogen, prepared from n.butyl lithium (2.3 ml) and diisopropylamine (0.51 ml), at -70° was treated with diethyl-N-isobutylphosphonoacetamide (0.46 g) in dry tetrahydrofuran. After 2 hours at 25° the above ketone (0.5 g) was added. After 18 hours at 25° water was added and the mixture worked up in the normal manner. Purification by chromatography (silica. ether/hexane) gave the title compound (0.24 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05202356 |
| Source dataset | uspto-grants-1993_04 |
| ORD ID | ord-9dc856f7a3b94f3e8b6fc6839a7b3f8f |
| Source note | uspto-grants-1993_04 |