HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfoxide → 4-Benzylbenzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4-(Phenylmethyl)benzenemethanol | HCID 597614 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Benzylbenzaldehyde | HCID 49886 | 53.3% |
Reaction Steps
The above alcohol (2.52 g) was oxidised using the conditions of Swern (oxalyl chloride, 1.2 ml; dimethyl sulphoxide, 1.8 ml; triethylamine, 8.8 ml) in dichloromethane to give 4-benzylbenzaldehyde (1.33 g). NMR 1H: 9.93(1H,s), 7.78(2H,d), 7.33(2H,d), 7.20(5H,s), 4.04(2H,s).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05202356 |
| Source dataset | uspto-grants-1993_04 |
| ORD ID | ord-7da4833d36024f7fb1dd4632f8293be7 |
| Source note | uspto-grants-1993_04 |