Sodium Hydroxide → HCID 14550003, compound

HRID 1590435Notes

Reaction equation

HRID 1590435 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[C:6]([CH2:11][S:12][CH3:13])[CH:5]=1)([O-])=O.[OH-].[Na+].S(S([O-])=O)([O-])=O.[Na+].[Na+]>O>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[C:6]([CH2:11][S:12][CH3:13])[CH:5]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 24489Sodium DithioniteHCID 13383862HCID 13383862, compound

Product 1

HCID 14550003HCID 14550003, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.085 moles (17 g) of 4-nitro-2-[(methylthio)methyl]phenol are added to a solution of 16 g of sodium hydroxide (NaOH) pellets in 135 ml of water, followed portionwise, so as to maintain the temperature between 70° C. and 75° C., by 55 g of sodium hydrosulphite. After the end of addition stirring is continued for 30 minutes at 75° C. After cooling, the expected product is obtained by neutralizing the reaction mixture with acetic acid. After filtering off, followed by washing with water and drying, it is recrystallized from 96° ethanol. It melts at 166° C. Analysis of the product obtained gives the following results:

Workup

  1. temperatureso as to maintain the temperature between 70° C. and 75° C.
  2. additionAfter the end of addition
  3. temperatureAfter cooling

Sources & evidence

ORD record
ord-e12974967b2f42bba3edc7d24f352ad9
Source dataset
uspto-grants-1993_04
Patent number
US05202487

Reaction notes

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