Maleic Acid → HCID 67885874, compound

HRID 1590468Notes

Reaction equation

HRID 1590468 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:14]=1[NH:13][C:12]1[CH2:11][CH2:10][CH:9]([CH2:15][C:16]3[N:17]=[CH:18][NH:19][C:20]=3[CH3:21])[C:8](=[O:22])[C:7]2=1.[C:23]([OH:30])(=[O:29])/[CH:24]=[CH:25]\[C:26]([OH:28])=[O:27]>C(O)C>[C:23]([OH:30])(=[O:29])/[CH:24]=[CH:25]\[C:26]([OH:28])=[O:27].[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:14]=1[NH:13][C:12]1[CH2:11][CH2:10][CH:9]([CH2:15][C:16]3[N:17]=[CH:18][NH:19][C:20]=3[CH3:21])[C:8](=[O:22])[C:7]2=1

Participants

4

Reactant 2

HCID 444266Maleic AcidHCID 19769824HCID 19769824, compound

Product 1

HCID 67885874HCID 67885874, compoundYield 76.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

8-Fluoro-1,2,3,9-tetrahydro-3-[(5-methyl-1H-imidazol-4-yl)methyl]-4H -carbazol-4-one (330 mg) was dissolved in dry ethanol (20 ml). Maleic acid (129 mg) in ethanol (10 ml) was added, and the solution was evaporated in vacuo. The residue was triturated with ether and the resultant solid was crystallised from ethanol:ether to give the title compound (351 mg), m.p. 174°-177°.

Workup

  1. customthe solution was evaporated in vacuo
  2. customThe residue was triturated with ether
  3. customthe resultant solid was crystallised from ethanol

Sources & evidence

ORD record
ord-ccb06152d5204b23927e030a958b9b3c
Source dataset
uspto-grants-1993_04
Patent number
US05202343

Reaction notes

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