HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1590547Generated: October 26, 2026
1,2-Difluorobenzene → 1-(4'-n-Pentyl-2,3-difluorobiphenyl-4-yl)-2-(4-propylphenyl)-ethane
https://huagongshe.com/reaction/1590547
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,2-Difluorobenzene | HCID 9706 | — |
| Reactant | 4-Pentylcyclohexanone | HCID 566097 | — |
| Reactant | 2,3-Difluoro-4'-pentyl-1,1'-biphenyl | HCID 10587425 | — |
| Reactant | 1-(4-Propylphenyl)-2-iodoethane | HCID 19767246 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Hexane | HCID 8058 | — |
| Solvent | 2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- | HCID 81646 | — |
| Product | 1-(4'-n-Pentyl-2,3-difluorobiphenyl-4-yl)-2-(4-propylphenyl)-ethane | HCID 19767228 | — |
Reaction Steps
0.15 mol of a solution of n-BuLi in hexane is added dropwise to a mixture of 0.1 mol of 4'-n-pentyl-2,3-difluorobiphenyl (prepared from 1,2-difluorobenzene and 4-pentylcyclohexanone analogously to Example 3), in 250 ml of THF and 0.1 mol of potassium tert. butylate at -90° C. After stirring for 10 minutes at -85° C. a solution of 0.1 mol of 1-(4-propylphenyl)-2-iodoethane in 50 ml of THF and 2 ml of DMPU is added dropwise. After warming up to -40° C. and customary work-up 1-(4'-n-pentyl-2,3-difluorobiphenyl-4-yl)-2-(4-propylphenyl)-ethane is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05204019 |
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| Source dataset | uspto-grants-1993_04 |
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| ORD ID | ord-b00ad94cdf4d4a928433a283bac12db9 |
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| Source note | uspto-grants-1993_04 |
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