Lawesson's reagent → HCID 57157513, compound

HRID 1590586Notes

Reaction equation

HRID 1590586 reaction equation
[CH2:1]([N:3]([CH2:31][CH3:32])[C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:13]2[CH2:17][CH:16]([O:18][Si:19]([CH3:29])([CH3:28])[C:20]([CH3:27])([CH3:26])[CH2:21]C(C)(C)C)[CH2:15][C:14]2=O)(=[O:12])=[O:11])=[CH:6][CH:5]=1)[CH3:2].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:42])=CC=1>C1(C)C=CC=CC=1>[CH2:1]([N:3]([CH2:31][CH3:32])[C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:13]2[CH2:17][CH:16]([O:18][Si:19]([C:20]([CH3:27])([CH3:26])[CH3:21])([CH3:29])[CH3:28])[CH2:15][C:14]2=[S:42])(=[O:12])=[O:11])=[CH:6][CH:5]=1)[CH3:2]

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 67887935HCID 67887935, compound

Product 1

HCID 57157513HCID 57157513, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 3.14 g of the product obtained in Stage A above 1.55 g of Lawesson reagent in 40 cm3 of toluene is taken to reflux for 4 hours. The solvent is evaporated under reduced pressure and the residue is chromatographed on silica (eluant: ethyl acetate - hexane 3-7). 2.45 g of desired product is obtained. M.p.=136° C. (after dissolution in ethyl acetate, filtration, evaporation to dryness, impasting in hexane).

Workup

  1. temperatureto reflux for 4 hours
  2. customThe solvent is evaporated under reduced pressure
  3. customthe residue is chromatographed on silica (eluant: ethyl acetate - hexane 3-7)

Sources & evidence

ORD record
ord-f40bdb363e1a4081a99235bb289c3f47
Source dataset
uspto-grants-1993_04
Patent number
US05204341

Reaction notes

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