Sodium Bicarbonate → HCID 57126064, compound

Participants

Reaction Steps

30 cm3 of sodium bicarbonate is added at -20° C. over one hour to a solution of 1.3 g of 1-[[4-(diethylamino)-phenyl]-sulphonyl]-4-[(1,1-dimethylethyl)-dimethylsilyloxy]-2-pyrrolidine thione obtained above, in 30 cm3 of methylene chloride. The mixture is agitated for 16 hours at ambient temperature, decanted, extracted with methylene chloride, the extracts are dried and evaporated to dryness. After crystallization from a chloroform - hexane mixture, 700 mg of the desired product is obtained. M.p=149-150° C.

Provenance & Evidence