Acetic Anhydride → HCID 19767598, compound

Participants

Reaction Steps

23.19 g (69.2 mmoles) of 1-(3-chlorophenyl)-3-hydroxymethyl-6,7-dimethoxyisochromane are dissolved in 100 ml of acetic anhydride. The reaction mixture is boiled for 3 hours under reflux, then it is evaporated in vacuo, and three times 50 ml each of 99.5% ethanol are distilled off the residual gum in vacuo. Thus 24.8 g of crude 1-(3-chlorophenyl)-3-acetoxymethyl-6,7-dimethoxyisochromane are obtained. Yield: 95%.

Provenance & Evidence