Ethyl diazoacetate → HCID 53828457, compound

Participants

Reaction Steps

Cyclopropanecarbonyl chloride (36 g, 0.34 mol) was added dropwise to a stirred solution of ethyl diazoacetate (86.2 g, 0.76 mol) in dry ether (500 ml) at 0° C. under a nitrogen atmosphere. The mixture was allowed to warm to room temperature then was stirred for 1 day, heated to gentle reflux for 2 days, then left to stand at room temperature for 5 days. Evaporation of the mixture followed by distillation afforded ethyl 3-cyclopropyl-2-diazo-3-oxo-propanoate (27.4 g, 44%) bp 85°-90° at 1 mm Hg).

Provenance & Evidence