HCID 19767497, compound → HCID 19767491, compound

HRID 1590604Notes

Reaction equation

HRID 1590604 reaction equation
[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1.[CH:12]1([C:16]2([CH2:20][OH:21])[CH2:19][O:18][CH2:17]2)[CH2:15][CH2:14][CH2:13]1>ClCCl.C(OCC)C>[CH:12]1([C:16]2([CH:20]=[O:21])[CH2:19][O:18][CH2:17]2)[CH2:15][CH2:14][CH2:13]1

Participants

5

Reactant 2

HCID 19767497HCID 19767497, compoundHCID 178418287HCID 178418287, compound

Product 1

HCID 19767491HCID 19767491, compoundYield 75.8%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

To a stirred suspension of pyridinium chlorochromate (10 g, 45 mmol) in dry dichloromethane (100 ml) was added 3-cyclobutyl-3-hydroxymethyloxetane (5 g, 35 mmol). The mixture was stirred for 2 hours, diluted with diethylether and then purified on a florisil column with an ether rinse. Evaporation afforded 3-cyclobutyl-3-formyloxetane (3.72 g, 75%) as a liquid.

Workup

  1. custompurified on a florisil column with an ether
  2. washrinse
  3. customEvaporation

Sources & evidence

ORD record
ord-4849ea9f3d2e45c58eeff08eec26667f
Source dataset
uspto-grants-1993_04
Patent number
US05204333

Reaction notes

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