Water → HCID 19767498, compound

Participants

Reaction Steps

2,2-Dimethyl-5-(3,4-difluorophenyl)-5-hydroxymethyl-1,3-dioxane (1.0 g) and Dowex 50×8-200 ion exchange resin (H+ form) (100 mg) in methanol (100 ml) containing water (20 ml) was heated to reflux with stirring for 3 hours. The cooled solution was filtered and evaporated to leave 2-(3,4-difluorophenyl)-2-hydroxymethylpropane-1,3-diol (0.45 g) as a yellow gum. Nmr. (d6 acetone) δ 7.5 (1H,m), 7.3 (1H,m), 7.2 (1H,m), 3.95 (6H,s), 4.2-3.8 (3H,broad).

Provenance & Evidence