HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 4-(6-Methylimidazo[1,2-a]pyridin-2-yl)benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 4-(6-Methylimidazo[1,2-a]pyridin-2-yl)benzonitrile | HCID 735912 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 4-(6-Methylimidazo[1,2-a]pyridin-2-yl)benzaldehyde | HCID 821055 | — |
Reaction Steps
1.0 g of 6-methyl-2-(4'-cyanophenyl)imidazo[1,2-a]-pyridine in 20 ml dry benzene was treated with Dibal (5.5 ml of 1M solution). After stirring for 2-3 hrs, methanol 15 ml was added, followed by 10 ml of 10% H2SO4. The precipitate was filtered, dissolved in water and basified with 15% NaOH. The collected precipitate was recrystallized from ethanol. Yield 0.68 g (68%); mp 210°-211° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05204352 |
| Source dataset | uspto-grants-1993_04 |
| ORD ID | ord-9cd1722affe942508d49bbc475a097a8 |
| Source note | uspto-grants-1993_04 |