Formamide → HCID 135463614, compound

HRID 1590630Notes

Reaction equation

HRID 1590630 reaction equation
[NH2:1][C:2]1[N:6]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[F:14])[N:5]=[N:4][C:3]=1[C:15]([NH2:17])=[O:16].[CH:18](N)=O>>[F:14][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[CH2:7][N:6]1[C:2]2[N:1]=[CH:18][NH:17][C:15](=[O:16])[C:3]=2[N:4]=[N:5]1

Participants

3

Reactant 2

HCID 713FormamideHCID 10823631HCID 10823631, compound

Product 1

HCID 135463614HCID 135463614, compound

Procedure

70,5 g (0.3 mol) of 5-amino-1-(2-fluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and 339 g (300 ml; 7.53 mol) of formamide are heated at a gentle boil for 2 hours. The reaction solution is then allowed to cool to approximately 100° and poured onto 2 l of ice-water. The precipitated product is filtered off with suction and washed with water. Drying at 100° yields 3-(2-fluorobenzyl)-3H,6H,7H-1,2,3-triazolo[4,5-d]pyrimidin-7-one having a melting point of 215°-218°.

Workup

  1. temperatureto cool to approximately 100°
  2. filtrationThe precipitated product is filtered off with suction
  3. washwashed with water
  4. customDrying at 100°

Sources & evidence

ORD record
ord-ea8ae44fbe774f7dbdfc5feed3198dbe
Source dataset
uspto-grants-1993_04
Patent number
US05204353

Reaction notes

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