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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1590644Generated: November 3, 2026

4-(3-Chloro-2-hydroxypropyl)-1-diphenylmethylpiperazine → 5-[3-(4-Diphenylmethylpiperazine-1-yl)-2-hydroxypropylthio]quinoline

https://huagongshe.com/reaction/1590644

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(3-Chloro-2-hydroxypropyl)-1-diphenylmethylpiperazineHCID 10360175—
ReactantQuinoline-5-thiolHCID 135755324—
Product5-[3-(4-Diphenylmethylpiperazine-1-yl)-2-hydroxypropylthio]quinolineHCID 1522813520.3%

Reaction Steps

Following the same procedure as in Example 23-(c), reaction and treatment were carried out using 220 mg of 5-quinolinethiol and 1.2 g of 4-(3-chloro-2-hydroxypropyl)-1-(diphenylmethyl)piperazine, in order to obtain 130 mg of 5-[3-(4-diphenylmethylpiperazine-1-yl)-2-hydroxypropylthio]quinoline.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05204348
Source datasetuspto-grants-1993_04
ORD IDord-76a8d05ec43846929c31af79b8459b35
Source noteuspto-grants-1993_04