Water → HCID 368387, compound

Participants

Reaction Steps

Concentrated HC1 (8 drops) was slowly added to a solution of 1-(3-diethylamino-2-hydroxypropylamino)-4-(3-chloro-2-hydroxypropylamino)-9, 10-anthracenedione (0.531 g, 2.36 mmol) in acetone-dichloromethane (50%, 15 mL). A color change from purple to red was observed. The solid was obtained by filtration, mp 106°-108° C., extremely hygroscopic. 1H NMR (D2O) δ 1.40 (t, J=7.3 Hz, 6H, CH3), 2.90 (m, 4H, CH2), 3.29 (m, 4H, CH2), 3.38 (m, 3H, CH2, CH), 3.73 (m, 3H, CH2, CH), 3.92 (broad, 1H, NH), 4.15 (broad, 1H, NH), 6.23 (s, 2H, ArH (2, 3)), 7.26 (m, 2H, ArH (6, 7)), 7.32 (m, 2H, ArH (5, 8)). Anal. Calcd for C24H30ClN 3 O4 2HCl 1.5 H2O: C, 51.48; H, 6.30; N, 7.50. Found: C, 51.70; H, 6.35; N, 7.41.

Provenance & Evidence