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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1590717Generated: October 31, 2026

2-(Chloromethyl)quinoline hydrochloride → 3-[n-(p-Chlorobenzyl)-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acid

https://huagongshe.com/reaction/1590717

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Chloromethyl)quinoline hydrochlorideHCID 3083823—
ReactantMethyl 3-[N-(p-chlorobenzyl)-5-hydroxyindol-2-yl]-2,2-dimethylpropanoateHCID 14980565—
Product3-[n-(p-Chlorobenzyl)-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acidHCID 18947621—

Reaction Steps

The title compound was prepared by treating the ester from Step A with 2-(choromethyl)quinoline hydrochloride under the conditions of Step D and effecting hydrolysis under the conditions of Example 1 (Step B), m.p. 193°-194° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05204344
Source datasetuspto-grants-1993_04
ORD IDord-c97d5823cdf84e40824658e64bfed32c
Source noteuspto-grants-1993_04