反应详情

To a suspension of 425 mg of p-chlorobenzoate from Step A in 3 mL of MeOH was added 1.9 mL of a solution of 1.3M NaOMe in MeOH. The mixture was stirred at R.T. for 1 h, poured into 20 mL of 25% aq. NH4OAc, and extracted with ethyl acetate. The organic extract was dried over Na2SO4 and evaporated to dryness to give an oil which was chromatographed on flash silica gel using ethyl acetate:hexane (30:70 as eluant to give the title compound as a white foam.

1. extractionextracted with ethyl acetate
2. extractionThe organic extract
3. dry with materialwas dried over Na2SO4
4. customevaporated to dryness
5. customto give an oil which
6. customwas chromatographed on flash silica gel