HRID1590758

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID86628724

未命名化合物

反应SMILES：CC(C)(C)OC(=O)N[C@@H](Cc1cn(-c2ccc([N+](=O)[O-])cc2[N+](=O)[O-])cn1)C(=O)O.[NH-][C@@H](CC1CCCCC1)[C@@H](O)CCCc1ccccn1

HCID131717863

未命名化合物

PRODUCTS

产物

反应SMILES：Cl.N[C@@H](Cc1cn(-c2ccc([N+](=O)[O-])cc2[N+](=O)[O-])cn1)C(=O)O.[NH-][C@@H](CC1CCCCC1)[C@@H](O)CCCc1ccccn1

HCID131717862

未命名化合物

PROCEDURE

实验过程

230 mg of Boc-His(DNP)-1(S)-cyclohexylmethyl-2(S)-hydroxy-5-(2-pyridyl)-pentylamide are stirred in 5 ml of saturated DME/HCl for 90 minutes and subsequently concentrated. 220 mg of the title compound are obtained as a resin.

WORKUP

后处理

concentrationsubsequently concentrated

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-647e636cec69449d9d6c4cdcaf7ff393
来源数据集: uspto-grants-1993_04
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US05204357
来源说明: uspto-grants-1993_04

反应SMILES

[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:21]([OH:23])=[O:22])[CH2:3][C:4]1[N:8]=[CH:7][N:6]([C:9]2[CH:20]=[CH:19][C:15]([N+:16]([O-:18])=[O:17])=[CH:14][C:10]=2[N+:11]([O-:13])=[O:12])[CH:5]=1.[CH:31]1([CH2:37][C@H:38]([NH-:50])[C@@H:39]([OH:49])[CH2:40][CH2:41][CH2:42][C:43]2[CH:48]=[CH:47][CH:46]=[CH:45][N:44]=2)[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1.COCCOC.[ClH:57]>>[NH2:1][C@H:2]([C:21]([OH:23])=[O:22])[CH2:3][C:4]1[N:8]=[CH:7][N:6]([C:9]2[CH:20]=[CH:19][C:15]([N+:16]([O-:18])=[O:17])=[CH:14][C:10]=2[N+:11]([O-:13])=[O:12])[CH:5]=1.[ClH:57].[CH:31]1([CH2:37][C@H:38]([NH-:50])[C@@H:39]([OH:49])[CH2:40][CH2:41][CH2:42][C:43]2[CH:48]=[CH:47][CH:46]=[CH:45][N:44]=2)[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1