HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → HCID 178448020, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 5-Bromo-2-ethoxypyridine | HCID 817237 | — |
| Reactant | Lithium | HCID 3028194 | — |
| Reactant | HCID 178448001 | HCID 178448001 | — |
| Catalyst | Zinc bromide | HCID 10421208 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178448020 | HCID 178448020 | — |
Reaction Steps
0.02 m of trans-4-(trans-4-propylcyclohexyl)-cyclohexylbromide, 0.04 m of lithium, 0.01 m of ZnBr2, 40 ml of toluene and 12 ml of THF are stirred at 0°-10° for 2 hours under ultrasonic. The 0.02 m of 5-bromo-2-ethoxy-pyridine and 0.5 g Pd (Ph3P)4 as the catalyst are added, and the mixture is stirred for further 4 hours at room temperature. Customary work-up yields 2-ethoxy-5-[trans-4-(trans-4-propylcyclohexyl)cyclohexyl]-pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05204477 |
| Source dataset | uspto-grants-1993_04 |
| ORD ID | ord-c781d56261e64926b917ec27bf424004 |
| Source note | uspto-grants-1993_04 |